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目的分析激素替代治疗对老年甲状腺功能减退患者认知功能的影响。方法 72例老年甲状腺功能减退患者,对所有患者采用激素替代治疗。对治疗前后患者的甲状腺激素水平、认知功能指标进行对比。结果患者治疗前游离三碘甲状腺原氨酸(FT_3)水平为(2.15±0.48)pmol/L、游离甲状腺素(FT_4)水平为(4.62±0.93)pmol/L、血清促甲状腺素(TSH)水平为(63.13±9.43)mIU/L;治疗6个月后,FT_3、FT_4水平分别为(6.33±0.84)、(15.05±6.09)pmol/L,TSH水平为(12.85±2.06)mIU/L。与治疗前比较,治疗后患者FT_3与FT_4水平显著上升、TSH水平显著下降,差异具有统计学意义(P<0.05)。治疗前,患者的简易精神状态量表(MMSE)评分为(14.32±2.85)分,治疗后为(25.32±2.95)分,治疗前后对比差异具有统计学意义(P<0.05)。结论对老年甲状腺功能减退患者应用激素替代治疗能够改善患者的激素水平、提高认知功能,具有很高的临床应用价值。
Objective To analyze the effect of hormone replacement therapy on cognitive function in elderly patients with hypothyroidism. Methods 72 elderly hypothyroidism patients, all patients with hormone replacement therapy. Before and after treatment of thyroid hormone levels, cognitive function indicators were compared. Results The level of free triiodothyronine (FT_3) was (2.15 ± 0.48) pmol / L, the level of free thyroxine (FT_4) was (4.62 ± 0.93) pmol / L and the level of serum thyroxine (TSH) (63.13 ± 9.43) mIU / L respectively. The levels of FT_3 and FT_4 were (6.33 ± 0.84) and (15.05 ± 6.09) pmol / L and (12.85 ± 2.06) mIU / L respectively after 6 months of treatment. Compared with those before treatment, FT_3 and FT_4 levels increased significantly and TSH level decreased significantly after treatment (P <0.05). Before treatment, the MMSE score was (14.32 ± 2.85) points and (25.32 ± 2.95) points after treatment. The difference between before and after treatment was statistically significant (P0.05). Conclusion Hormone replacement therapy in elderly patients with hypothyroidism can improve the patient’s hormone levels and improve cognitive function, with high clinical value.