【摘 要】
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Aberrant microRNA (miRNA) expression plays a critical role in osteosarcoma (OS) pathogenesis.In this study,we elucidated the involvement of miR-487a in OS and t
【机 构】
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Department of Orthopedics, Hwa Mei Hospital, University of Chinese Academy of Sciences(Ningbo No.2 H
论文部分内容阅读
Aberrant microRNA (miRNA) expression plays a critical role in osteosarcoma (OS) pathogenesis.In this study,we elucidated the involvement of miR-487a in OS and the underlying molecular mechanisms.We found that miR-487a was upregulated in OS clinical samples and cell lines.Knockdown of miR-487a suppressed OS cell growth and invasion and induced apoptosis;however,overexpression of miR-487a promoted OS cell growth and invasion.Accordingly,downregulation of miR-487a significantly suppressed tumor growth of OS xenografts in vivo.Furthermore,B-cell translocation gene 2 (BTG2) mRNA was found to be a novel target of miR-487a.Knockdown of BTG2 using small interfering RNA (siRNA) recapitulated the oncogenic effects of miR-487a,whereas BTG2 overexpression partially reversed these effects.Finally,miR-487a levels were found to be negatively correlated with BTG2 expression in OS clinical samples.Collectively,our data suggest that miR-487a is an oncogenic miRNA in OS and it lowers BTG2 expression.
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