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目的:评价口服迈之灵对预防和治疗体外受精-胚胎移植（n in vitro fertilization-embryo transfer， IVF-ET）后卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）发生及其严重程度的作用。n 方法:选择2018年2月至2019年10月期间在中山大学附属第六医院行IVF-ET助孕取卵术后因OHSS高风险取消移植的100例患者，前瞻性随机对照分组，试验组患者（50例）取卵术后口服迈之灵300 mg，bid×10 d，对照组患者无迈之灵治疗，其他治疗一致，比较两组之间OHSS发生率以及严重程度。结果:女方年龄、体质量指数（body mass index，BMI）、抗苗勒管激素（anti-Müllerian hormone，AMH）、促性腺激素（gonadotropin，Gn）使用总量、获卵数等基本条件组间比较差异均无统计学意义（n P>0.05），试验组与对照组中重度OHSS发生率差异有统计学意义［4.00%（2/50）比18.00%（9/50），n P=0.025］，对照组腹水穿刺3例，试验组腹水穿刺0例，无重度OHSS发生。n 结论:口服迈之灵能有效预防OHSS高危患者的中重度OHSS发生率，并降低OHSS严重程度。“,”Objective:To evaluate the effect of oral Aescuven forte on the incidence and severity of ovarian hyperstimulation syndrome (OHSS).Methods:A total of 100 patients who cancelled transplantation after oocyte retrieval for n in vitro fertilization-embryo transfer assisted reproduction due to high risk of OHSS between February 2018 and October 2019 in Reproductive Medicine Research Center, the Sixth Affiliated Hospital, Sun Yat-Sen University were randomized into two groups in this prospective randomized controlled trial. The patients in experimental group (50 cases) received 300 mg, bid of Aescuven forte orally for 10 d after oocyte retrieval, while control group (50 cases) did not receive Aescuven forte; otherwise, both groups underwent the same treatments. The incidence rate and severity of OHSS were compared between the two groups.n Results:No significant differences were found in variables such as age, body mass index (BMI), anti-Müllerian hormone (AMH) level, total dosage of gonadotropin (Gn) used, and the number of retrieved oocytes between the two groups (n P>0.05). The incidence rate of moderate to severe OHSS in experimental group and control group was 4.00% (2/50) and 18.00% (9/50), respectively, with a statistically significant difference (n P=0.025). Control group included 3 cases of paracentesis due to ascites, while experimental group did not include any cases of paracentesis or severe OHSS.n Conclusion:Oral administration of Aescuven forte effectively prevent the incidence of moderate to severe OHSS in high-risk patients and reduced the severity of OHSS.