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目的了解深圳地区淋球菌临床分离株对抗生素的敏感性以及头孢曲松中敏株的流行特点。方法收集2008年自本地区患者中分离的淋球菌196株,同时整理相应患者信息资料,采用琼脂稀释法测定四环素、环丙沙星、头孢曲松、大观霉素对淋球菌的最低抑菌浓度(MIC),用头孢硝噻吩纸片测定β-内酰胺酶。结果 196株淋球菌中检出产β-内酰胺酶的淋球菌(PPNG)70株(35.71%),质粒介导的高度耐四环素菌株(TRNG)131株(66.84%),对环丙沙星耐药率达95.41%,对头孢曲松中敏率为33.16%,未发现对头孢曲松和大观霉素耐药菌株,对淋球菌头孢曲松中敏株和高敏株进行人群资料分析发现两组的PPNG检出率差异具有统计学意义。结论深圳地区淋球菌耐药性已较严重,头孢曲松中敏株的流行特点尚未明确,应加强对淋球菌耐药性的监测及流行病学的研究。
Objective To understand the antibiotic sensitivity of Neisseria gonorrhoeae isolates in Shenzhen and the prevalence of susceptible strains in ceftriaxone. Methods Ninety-six Neisseria gonorrhoeae strains were isolated from patients in this area in 2008, and the corresponding patient information was collected. The minimum inhibitory concentrations of tetracycline, ciprofloxacin, ceftriaxone and spectinomycin against Neisseria gonorrhoeae were determined by agar dilution method (MIC), β-lactamase was determined using cephalexin paper. Results 70 strains (35.71%) of gonococcal strains producing β-lactamase (PPNG) and 131 strains (66.84%) of tetracycline-resistant strains (TRNG) were detected in 196 strains of gonococci. Resistant rate was 95.41%, the sensitivity rate of ceftriaxone was 33.16%, no ceftriaxone and spectinomycin resistant strains were found, and Neisseria gonorrhoeae ceftriaxone susceptible and hypersensitive strains of the population data analysis found that two groups of PPNG detection rate difference was statistically significant. Conclusion Neisseria gonorrhoeae resistance has been more serious in Shenzhen. The epidemic characteristics of ceftriaxone susceptible strains are not yet clear. Therefore, the surveillance and epidemiological study of Neisseria gonorrhoeae resistance should be strengthened.