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目的 探讨肝静脉阻断对实验性肝癌生长的影响。方法 以Wistar大鼠肝癌模型为材料 ,采用免疫组化SUPERVISION两步法观察肝静脉阻断后肝癌、癌周、邻近肝叶 (肝左中叶 )及肺组织血管内皮生长因子 (VEGF)的表达。结果 肝静脉结扎组肝癌及癌周组织VEGF的表达较对照组明显下调 (P <0 0 1 ) ,肝左中叶较对照组明显上调 (P <0 0 1 ) ,肺组织VEGF的表达较对照组也明显上调 (P <0 0 5)。结论 肝癌肝静脉阻断可抑制局部肿瘤的生长 ,但有提高肿瘤肝内侵袭及远隔器官转移的可能性
Objective To investigate the effect of hepatic vein occlusion on the growth of experimental liver cancer. Methods The Wistar rat hepatocellular carcinoma model was used as the material. Immunohistochemistry SUPERVISION two-step method was used to observe the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC), perirenal region, adjacent liver lobe (middle liver) and lung tissue after hepatic vein occlusion. Results The expression of VEGF in hepatocellular carcinoma and pericancerous tissue in hepatic vein ligation group was significantly lower than that in control group (P <0.01). The left middle lobe of hepatic tissue was significantly up-regulated compared with control group (P <0.01) Also significantly up-regulated (P <0.05). Conclusion Hepatic vein hepatic vein occlusion can inhibit the growth of local tumor, but it has the possibility of increasing intrahepatic invasion and distant organ metastasis.