糖尿病肾病的防治是糖尿病慢性并发症防治研究的一项重要课题。研究显示 ,血管紧张素受体拮抗剂能够降低尿蛋白排泄量 ,延缓肾动脉硬化及肾脏纤维化的进展 ,对肾脏具有显著的保护作用。目前认为 ,这一作用是通过多种途径实现的 ,除降低血压带来的益处外 ,还存在非血流动力学方面的作用 ,如抑制细胞外基质在肾脏局部的积聚、下调肾脏皮质转化生长因子 β的表达、减少肾脏细胞凋亡、改善肾组织的高代谢状态和抗过氧化酶活性等。近年来 ,一些重要的大型临床试验如RENAAL研究等证明了血管紧张素受体拮抗剂在糖尿病肾病防治中的地位与作用 Prevention and treatment of diabetic nephropathy is an important issue of prevention and treatment of chronic complications of diabetes mellitus. Studies have shown that angiotensin receptor antagonists can reduce urinary protein excretion, delay renal arteriosclerosis and renal fibrosis, has a significant protective effect on the kidneys. At present, this role is achieved through a variety of ways, in addition to reducing the benefits of blood pressure, there are also non-hemodynamic aspects of the role, such as inhibition of extracellular matrix accumulation in the kidney, down regulation of renal cortical metaplasia Factor β expression, reduce renal cell apoptosis and improve renal metabolic status and anti-peroxidase activity. In recent years, some important large-scale clinical trials such as the RENAAL study have demonstrated the role of angiotensin receptor blockers in the prevention and treatment of diabetic nephropathy