We present the experiment observation of a giant topological Hall effect (THE) in a frustrated kagome bilayer magnet Fe3Sn2. The negative topologically Hall resistivity appears when the field is below 1.3 T and it increases with increasing temperature up to 300 K. Its maximum absolute value reaches ～2.01 μ?·cm at 300 K and 0.76 T. The origins of the observed giant THE can be attributed to the coexistence of the field-induced skyrmion state and the non-collinear spin configuration, possibly related to the magnetic frustration interaction in Fe3Sn2.