1病历资料患者男,58岁,因“反复咳嗽、咳痰、喘息50年,加重7 d伴嗜睡3 d”于2014-12-24入院。患者50年前出现咳嗽、咳痰、喘息,多在冬春季节发病,以晨起、接触刺激气体为重,偶伴有发热,每年发作加重3个月以上,未正规诊治。后来发作逐渐频繁,每次发作程度加重。近5年季节性不明显,且逐渐出现双下肢水肿、尿少,间断有意识改变、嗜睡,活动耐力明显下降。曾反复到我科就诊,未坚持规范治疗,自 1 patient data Male patient, 58 years old, because of “repeated cough, expectoration, wheezing 50 years, increased 7 d with lethargy 3 d ” was admitted to 2014-12-24. 50 years ago, patients with cough, sputum, wheezing, and more in the winter and spring onset, early morning exposure to irritating gas as heavy, accompanied by fever, exacerbations of more than 3 months each year, not formal diagnosis and treatment. Later episodes gradually frequent, each episode increased. The past five years seasonal is not obvious, and the gradual emergence of lower extremity edema, oliguria, intermittent conscious change, drowsiness, activity endurance decreased significantly. Has repeatedly to our department for treatment, did not adhere to standard treatment, since