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神经松弛剂所引起的类震颤性麻痹征,早于1950年应用氯丙嗪时即为人们所认识.因为其症状与脑炎后及特异性震颤性麻痹的症状相同,所以临床医生推断类阿托品药物既能治疗后者,便亦应能治疗前者.这种推断已为广泛的临床实践所证明.但是,最近有证据显示类阿托品药物会增加病人产生迟发性运动障碍的危险性.因此,有人主张只在用神经松弛剂治疗出现锥外系副作用后才用这类药物,而不作为预防用药.日益赞成这类药物的使用在有限的时间后便应停药,观察病人是否再出现类震颤麻痹的症状.此外,使用类阿托品药物时,应考虑到这类药物使以乙酰胆碱为传导介质的纹状体神经元系统长期受抑制,因而产生或加重其低胆碱能状态.抗震颤性麻痹多为类阿托品作用的药物(有抗纹状体乙酰胆碱的功能),所以我们希望能找出既可增加纹状体多巴胺的活性,又不阻断乙酰胆碱的作用,从而可恢复纹状体的多巴胺与乙酰胆碱平衡的一种药物.盐酸金刚烷胺没有抗胆碱的作用,推想它可增加中枢神经系统中多巴胺的活性,故已成为治疗特异性及脑类后震颤性麻痹的常用药物.本文研究的目的是探索它能否作为一种较长期服用而较少并发症的替换药物,来治疗药物引起的震颤性麻痹症.
Signs of tremor-like paralysis caused by neuroleptics were recognized as early as when chlorpromazine was used in 1950. Because their symptoms are the same as those after encephalitis and specific tremor paralysis, clinicians conclude that atropine However, recent evidence suggests that atropine-like drugs increase the risk of developing tardive dyskinesias, and as a result, It has been argued that these drugs should be used only after treatment with neuroleptic agents to prevent congenital side effects, rather than as a prophylaxis. Increasingly in favor of the use of such drugs should be discontinued after a limited period of time to see if the patient reappears In addition, the use of atropine-like drugs should be considered when such drugs cause long-term inhibition of acetylcholine-mediated striatal neuronal systems, resulting in or exacerbating their hypocholinergic state. Paralyzes mostly drugs that act like atropines (with anti-striatum acetylcholine function), so we wanted to find out that it would both increase dopamine activity in the striatum without blocking acetyl Choline, which can restore the striatum of dopamine and acetylcholine balance of a drug.Andazamine hydrochloride is not the role of anticholinergic, presumably it can increase dopamine activity in the central nervous system, it has become a treatment-specific And cerebellum after tremor paralysis commonly used drugs.The purpose of this study is to explore whether it can be used as a longer-term use and less complications of alternative drugs to treat drug-induced tremor paralysis.