植物凝集素是一种非免疫原性的蛋白质,在植物界广泛分布。它可以专一性地识别并结合单糖或寡糖,这种结合具有可逆性。植物凝集素与细胞表面表达的糖分子结合后能够引发细胞内一系列的生物化学反应,使细胞或机体代谢发生改变,例如诱导细胞凋亡和自噬。现就植物凝集素诱导肿瘤细胞凋亡和自噬可能的分子机制作一综述。 Phytohemagglutinin is a non-immunogenic protein widely distributed in the plant kingdom. It can specifically identify and combine monosaccharides or oligosaccharides, this combination is reversible. Binding of plant lectins to sugar molecules expressed on the cell surface triggers a series of biochemical reactions in the cell that alter the metabolism of cells or organisms, such as apoptosis and autophagy. A review is given on the possible molecular mechanisms of phytohemagglutinin-induced tumor cell apoptosis and autophagy.