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应用免疫酶标玻片法检测了宫颈癌高发区101例宫颈非典型增生、66例宫颈原位癌、61例宫颈浸润癌病人以及193例健康妇女血清中的 HSV-1和 HSV-2抗体。在年龄、初婚年龄、初产年龄、足月产次、结婚次数等与性行为和生育有关的因素方面将病人与健康妇女配对后,发现宫颈非典型增生、宫颈原位癌、宫颈浸润癌病人的 HSV-2抗体阳性率和几何平均滴度高于相应对照妇女。本研究提示 HSV-2感染与宫颈癌的发生有关联.
Serum HSV-1 and HSV-2 antibodies in 101 cases of cervical atypical hyperplasia, 66 cases of cervical carcinoma in situ, 61 cases of cervical invasive carcinoma and 193 healthy women were detected by immunostaining slide method. After pairing patients with healthy women in terms of age, first marriage age, first trimester age, full-term birth number, the number of marriages and other factors related to sexual behavior and childbirth, patients with cervical atypical hyperplasia, cervical carcinoma in situ and invasive cervical cancer were found HSV-2 antibody positive rate and geometric mean titer higher than the corresponding control women. This study suggests that HSV-2 infection is associated with the occurrence of cervical cancer.