目的 探究耳聋胶囊联合天麻素注射液治疗突发性耳聋的临床疗效.方法 选取2016年1月—2017年1月陕西省核工业二一五医院耳鼻咽喉科收治的突发性耳聋患者161例为研究对象,所有患者随机分为对照组(80例)和治疗组(81例).对照组肌内注射天麻素注射液,2 mL/次,1次/d.治疗组在对照组的基础上口服耳聋胶囊,3粒/次,2次/d.两组患者均治疗4周.观察两组的临床疗效,比较两组的言语频率平均听阈、症状消失时间和听力损失情况.结果 治疗后,对照组和治疗组的总有效率分别为85.00%、97.53%,两组比较差异有统计学意义(P<0.05).治疗后,两组言语频率平均听阈均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组言语频率平均听阈明显低于对照组,两组比较差异具有统计学意义(P<0.05).治疗后,治疗组呕吐、头晕、耳鸣消失时间明显短于对照组,两组比较差异有统计学意义(P<0.05).治疗后,两组轻度听力损失患者明显增加,中重度、重度和极重度患者明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组中重度、重度和极重度患者明显低于对照组,两组比较差异具有统计学意义(P<0.05).结论 耳聋胶囊联合天麻素注射液治疗突发性耳聋具有显著的临床疗效,能够改善患者的听力损失程度,缩短临床症状消失时间,安全性较好,具有一定的临床推广应用价值.“,”Objective To explore the clinical efficacy of Erlong Capsules combined with Gastrodin Injection in treatment of sudden deafness. Methods Patients (161 cases) with sudden deafness in Department of Otolaryngology Head and Neck Surgery of the No. 215 Hospital of Shaanxi Nuclear Industry from January 2016 to January 2017 were randomly divided into the control group (80 cases) and treatment group (81 cases). Patients in the control group were sc administered with Gastrodin Injection, 2 mL/time, once daily. Patients in the treatment group were po administered with Erlong Capsules on the basis of the control group, 3 grains/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and speech frequency average hearing threshold, symptom disappearance time, and hearing loss in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.00% and 97.53%, respectively, and there was difference between two groups (P < 0.05). After treatment, the speech frequency average hearing thresholds in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the speech frequency average hearing thresholds in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the symptom disappearance times of vomiting, dizziness, and tinnitus in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, patients with mild hearing loss in two groups were significantly increased, but patients with moderate, severe, and extremely severe hearing loss in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And patients with moderate, severe, and extremely severe hearing loss in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Erlong Capsules combined with Gastrodin Injection has clinical curative effect in treatment of sudden deafness, can improve the degree of hearing loss, and shorten symptom disappearance times, with good safety, which has a certain clinical application value.