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目的:探讨≥80岁急性脑梗死患者应用重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗的有效性。方法:选择发病4.5 h内予rt-PA静脉溶栓治疗急性脑梗死患者。根据年龄分为≥80岁组和<80岁组,比较两组患者溶栓前、溶栓后7d的NIHSS评分及90 d随访时m RS评分。结果:两组溶栓后7d的NIHSS评分都较溶栓前显著降低(P<0.05)。90 d随访,≥80岁组13例,<80岁组47例预后良好,两组预后良好例数比较差异无统计学意义。结论:≥80岁脑梗死患者应用rt-PA静脉溶栓治疗是有效的。
Objective: To investigate the effectiveness of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) in patients with acute cerebral infarction of age ≥ 80 years. Methods: Patients with acute cerebral infarction were treated with rt-PA intravenous thrombolysis within 4.5 hours. The patients were divided into two groups according to their age, ≥80 years old and <80 years old. NIHSS scores before thrombolysis, 7 days after thrombolysis and m RS scores at 90 days were compared between the two groups. Results: The NIHSS scores of the two groups after thrombolysis were significantly lower than those before thrombolysis (P <0.05). At 90-day follow-up, 13 patients ≥80 years old and 47 patients <80 years old had a good prognosis. There was no significant difference between the two groups in the number of good prognosis. Conclusion: rt-PA intravenous thrombolysis in patients with cerebral infarction ≥ 80 years is effective.