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目的 认识和分析骨形成蛋白 (BMP)及其信号传导因子与口腔鳞癌发生、发展的可能关系。 方法 用免疫组织化学方法检测 BMP- 5、 A型 BMP受体及 Smad1,4 ,5在 Tca8113舌癌细胞中的表达并分析其意义。结果 BMP- 5、 A型 BMP受体及 Sm ad1,4 ,5在 Tca8113细胞中有表达。其中在细胞质中发现有 BMP- 5的阳性信号 ,在细胞膜中有 A型 BMP受体的阳性信号 ,在细胞质、细胞核中有 Sm ad1,4 ,5的强阳性表达。 结论 BMP及其信号传导因子与口腔鳞癌发生发展有密切关系
Objective To understand and analyze the possible relationship between bone morphogenetic protein (BMP) and its signal transduction factors and the occurrence and development of oral squamous cell carcinoma. Methods The expression of BMP-5, type A BMP receptors and Smad1, 4 and 5 in Tca8113 tongue cancer cells were detected by immunohistochemistry and their significance was analyzed. Results BMP-5, type A BMP receptor and Sm ad1, 4, 5 were expressed in Tca8113 cells. Among them, positive signal of BMP-5 was found in the cytoplasm, positive signal of type A BMP receptor in the cell membrane, strong positive expression of Sm ad1,4,5 in cytoplasm and nucleus. Conclusion BMP and its signal transduction factors are closely related to the occurrence and development of oral squamous cell carcinoma