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食物的存在使第一代巯基类血管紧张素转换酶(ACE)抑制剂甲巯丙脯酸的吸收减少35～40%。喹那普利(Quinapril)是一种新的不含疏基ACE抑制剂,本研究是在健康志愿者中测定标准早餐对喹那普利及其活性二酸代谢物CL-928药动学的影响。 12名健康男性志愿者参加非盲、随机、双向交叉的研究。受试者在禁食8小时后或者在标准早餐后10分钟口服本品40 mg,给药后4小时恢复日常饮食,两种治疗间隔一周。在给药前取血样、尿样,用气-液色谱法分析喹那普利和CL-928。结果表明,口服本品40mg后,在禁食和进食组,平均最大血浆浓度(C_(max))、药-时曲
The presence of food reduced the absorption of the first generation of the sulfhydryl class of angiotensin converting enzyme (ACE) inhibitor captopril by 35 to 40%. Quinapril is a novel, non-sparse ACE inhibitor. This study determined the effect of standard breakfast on the pharmacokinetics of quinapril and its active diacid metabolite CL-928 in healthy volunteers influences. Twelve healthy male volunteers participated in a non-blind, randomized, two-way crossover study. Subjects were orally administered with 40 mg orally after 8 hours of fasting or 10 minutes after standard breakfast and returned to normal diet 4 hours after dosing, one week apart. Blood samples and urine samples were taken before administration and quinacrolone and CL-928 were analyzed by gas-liquid chromatography. The results showed that oral administration of 40mg, fasting and eating groups, the average maximum plasma concentration (C max), drug-hour song