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本文以小鼠未成熟卵母细胞的杀伤为效应指标,观察了不同能量中子的相对生物效应,从而进一步确定了这些高敏感性细胞致死效应的最小靶区以及靶的几何学特征。结果表明,0.43MeV中子(0～0.3Gy)照射14日龄小鼠,其卵母细胞存活率随剂量增加而降低(100%～0.3%),可用线性或线性平方模型表示。通过曲线拟合,得出LD_(50)为0.039Gy。对宫内胎鼠的卵母细胞存活的影响也存在剂量依赖性,但敏感性比14日龄小鼠低,其LD_(50)为0.15Gy。平均能量为2.15MeV的~(252)Cf裂变中子对14日龄小鼠的卵母细胞存活的影响表现为随剂量增加(0～0.219Gy)而降低(100%～6.7%),其LD_(50)为0.07Gy。有趣的是,此裂变中子对卵母细胞的效应比~(60)Co-γ线(LD_(50)=0.054Gy)还要弱。15MeV中子照射的结果和裂变中子相似,其LD_(50)为0.065Gy。γ线照射(0～0.3Gy)所致卵母细胞存活降低的LD_(50)为0.054Gy,此结果作为分析相对生物效应的参比标
In this paper, the killing effect of immature oocytes in mice was taken as the effect index, the relative biological effects of different energy neutrons were observed, and the minimum target area and the geometric characteristics of the target were further determined. The results showed that the 0. 04 MeV neutron (0 ~ 0.3Gy) irradiation 14-day-old mice, the oocyte survival rate decreased with increasing dose (100% ~ 0.3%), available linear or linear square model. By curve fitting, LD_ (50) was found to be 0.039Gy. The effect on intrauterine fetal rat oocyte survival was also dose-dependent, but its sensitivity was lower than that of 14-day-old mice with an LD 50 of 0.15 Gy. The effect of ~ (252) Cf fission neutrons with average energy of 2.15MeV on the viability of oocytes in 14-day-old mice showed a decrease (100% -6.7%) with increasing dose (0-0.219Gy) (50) is 0.07Gy. Interestingly, the effect of this fission neutron on oocytes was weaker than that of ~ (60) Co-γ line (LD_ (50) = 0.054Gy). The results of 15MeV neutron irradiation were similar to those of fission neutrons with LD50 of 0.065Gy. The LD_ (50) of oocytes that had a decreased viability of 0 ~ 0.3 Gy due to γ-ray irradiation was 0.054 Gy, which was used as a reference for the analysis of relative biological effects