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目的探讨氨氯地平联合瑞舒伐他汀钙治疗高血压合并颈动脉粥样硬化的临床疗效。方法选取江苏省兴化市人民医院2015—2016年收治的高血压合并颈动脉粥样硬化患者80例,随机分为观察组和对照组,各40例。观察组患者予以瑞舒伐他汀钙片联合苯磺酸氨氯地平片治疗,对照组患者予以苯磺酸氨氯地平片治疗,两组患者均连续治疗30 d。比较两组患者治疗前及治疗3、6个月后血压水平、颈动脉内膜中层厚度(IMT)、颈动脉粥样硬化病变体积(PV)和血清超敏C反应蛋白(hs-CRP)水平,观察两组患者不良反应发生情况。结果治疗前,两组患者收缩压、舒张压、颈动脉IMT与PV、血清hs-CRP水平比较,差异无统计学意义(P>0.05);治疗3、6个月后,观察组患者收缩压、舒张压及血清hs-CRP水平低于对照组,颈动脉IMT与PV小于对照组(P<0.05)。观察组总有效率为95.00%,高于对照组的82.50%(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论氨氯地平联合瑞舒伐他汀钙片治疗高血压合并颈动脉粥样硬化的临床疗效确切,可有效缓解患者临床症状,降低血压水平,且安全性较高。
Objective To investigate the clinical efficacy of amlodipine combined with rosuvastatin calcium in the treatment of hypertension and carotid atherosclerosis. Methods Eighty patients with hypertension and carotid atherosclerosis admitted to Xinghua People’s Hospital of Jiangsu Province from 2015 to 2016 were randomly divided into observation group and control group, 40 cases each. Patients in the observation group were treated with rosuvastatin calcium tablets combined with amlodipine besylate, and patients in the control group were treated with amlodipine besylate tablets. Both groups were treated for 30 days continuously. Blood pressure, carotid artery intima-media thickness (IMT), carotid atherosclerosis lesion volume (PV) and serum hs-CRP level were compared between the two groups before treatment and 3 and 6 months after treatment. , Observed two groups of patients with adverse reactions occurred. Results Before treatment, systolic blood pressure, diastolic blood pressure, carotid IMT and PV, serum hs-CRP levels were not significantly different between the two groups (P> 0.05). After 3 and 6 months of treatment, systolic blood pressure , Diastolic blood pressure and serum hs-CRP levels were lower than the control group, carotid artery IMT and PV less than the control group (P <0.05). The total effective rate was 95.00% in the observation group, which was higher than that in the control group (82.50%, P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Amlodipine combined with rosuvastatin calcium tablets in the treatment of hypertension combined with carotid atherosclerosis clinical curative effect, can effectively alleviate the clinical symptoms, lower blood pressure levels, and higher safety.