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目的 通过羟基喜树碱(HCPT)联合用药治疗晚期消化系肿瘤的临床观察,探讨提高疗效、降低化疗毒性、提高生存质量。方法 选用以羟基喜树碱为主的联合化疗方案,治疗晚期消化系恶性肿瘤48例。21天1周期,连用3个周期。结果 总效率(CR+PR)43.8％。CR3例,PR18例。结论 治疗晚期消化系恶性肿瘤,以羟基喜树碱联药的治疗方案,毒性小,耐受性好,疗效增高,值得进一步研究。
Objective To observe the clinical effects of HCPT combined with cisplatin in the treatment of advanced gastrointestinal cancers, and to explore the efficacy, reduce the toxicity of chemotherapy and improve the quality of life. Methods 48 patients with advanced digestive malignancies were treated with hydroxycamptothecine-based combination chemotherapy. 21 days and 1 cycle, use 3 cycles. Results The overall efficiency (CR+PR) was 43.8%. There were 3 cases of CR and 18 cases of PR. Conclusion In the treatment of advanced malignant tumors of the digestive system, the treatment plan of hydroxycamptothecin combined drug has little toxicity, good tolerability and higher curative effect, and it is worthy of further study.