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目的:探讨利巴韦林注射液联合痰热清治疗儿童流行性腮腺炎的疗效。方法:128例流行性腮腺炎患儿随机分为观察组和对照组各64例。对照组给予利巴韦林注射液5~7.5 mg·kg-1,ivd,bid;观察组在对照组基础上加用痰热清注射液0.25~0.4 ml·kg-1·d-1,ivd,qd。治疗5 d后观察两组腮腺肿痛消退时间、退热时间,及两组患者血清肿瘤坏死因子α(TNF-α)和C反应蛋白(CRP)的下降程度,比较两组疗效。结果:观察组总有效率为93.8%,明显高于对照组(P<0.05)。观察组腮腺肿痛消退时间及退热时间均明显短于对照组(P<0.05)。治疗后,两组患者的TNF-α、CRP水平均较治疗前明显改善(P<0.05),且观察组改善程度明显优于对照组(P<0.05)。结论:利巴韦林联合痰热清治疗儿童流行性腮腺炎,可以明显缩短腮腺肿痛消退时间和退热时间,抑制细胞因子TNF-α和CRP水平,疗效显著,值得临床推广及应用。
Objective: To investigate the curative effect of ribavirin injection combined with Tanreqing on children’s mumps. Methods: 128 cases of mumps were randomly divided into observation group and control group of 64 cases. The control group was given Ribavirin injection 5 ~ 7.5 mg · kg-1, ivd, bid. The observation group was treated with Tanreqing injection 0.25 ~ 0.4 ml · kg-1 · d-1 on the basis of the control group, ivd , qd. After 5 days of treatment, the parotid gland pain subsidence time, antipyretic time, and the decline of serum tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were compared between the two groups. Results: The total effective rate in the observation group was 93.8%, which was significantly higher than that in the control group (P <0.05). Parotid gland swelling and pain relieving time and antipyretic time in the observation group were significantly shorter than those in the control group (P <0.05). After treatment, the levels of TNF-α and CRP in both groups were significantly improved (P <0.05), and the improvements in the observation group were significantly better than those in the control group (P <0.05). Conclusion: Ribavirin combined with Tanreqing treatment of children with mumps can significantly reduce the parotid gland pain subsided time and antipyretic time, inhibit the levels of cytokines TNF-α and CRP, significant effect, worthy of clinical promotion and application.