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目的探讨免疫球蛋白在早产儿败血症辅助治疗中的作用机理及对治疗效果进行评估。方法 2012年1月—2014年12月在我院新生儿科诊治的早产儿败血症共118例,按诊断日期的单双号随机分成观察组58例和对照组60例,2组均给予常规抗感染治疗,观察组自诊断败血症之日起辅以免疫球蛋白治疗,每次400 mg/kg,每日1次,连用3 d,比较2组临床及实验室指标的恢复时间、病死率差异有无统计学意义,并比较2组治疗前后血清Ig G水平有无差异。结果观察组临床恢复时间早于对照组[(6.93±1.43)d vs.(8.47±2.13)d,P<0.05];观察组血WBC、PLT、CRP、PCT恢复正常的时间均较对照组早(P<0.05);观察组的病死率低于对照组(5.2%vs.16.7%,P<0.05);观察组治疗后血清Ig G水平较治疗前显著升高[(6.29±1.09)g/L vs.(11.14±1.79)g/L,P<0.01)],而对照组治疗前后血清Ig G水平差异无统计学意义[(6.37±1.14)g/L vs.(6.33±0.97)g/L,P>0.05]。结论免疫球蛋白可提高早产儿血清Ig G水平,增强早产儿的体液免疫功能,辅助治疗早产儿败血症有较好的疗效。
Objective To investigate the mechanism of immunoglobulin in the adjuvant treatment of sepsis in preterm infants and evaluate the therapeutic effect. Methods Seventy-one premature infants diagnosed and treated neonates in our hospital from January 2012 to December 2014 were randomly divided into observation group (58 cases) and control group (60 cases) according to the date of diagnosis. Both groups were given conventional anti-infection Treatment, the observation group since the date of diagnosis of sepsis supplemented with immunoglobulin treatment, each 400 mg / kg, once daily for 3 d, comparison of two groups of clinical and laboratory indicators of recovery time, the difference between the fatality rate Statistical significance, and compare the two groups before and after treatment of serum Ig G levels were no difference. Results The clinical recovery time of the observation group was earlier than that of the control group [(6.93 ± 1.43) d vs. (8.47 ± 2.13) d, P <0.05]. The WBC, PLT, CRP and PCT returned to normal in the observation group were earlier than those in the control group (P <0.05). The mortality of the observation group was lower than that of the control group (5.2% vs.16.7%, P <0.05). The serum IgG level of the observation group was significantly higher than that before treatment [(6.29 ± 1.09) g / L vs. (11.14 ± 1.79) g / L, P <0.01). However, there was no significant difference in serum Ig G level before and after treatment in the control group [(6.37 ± 1.14) g / L vs. (6.33 ± 0.97) g / L, P> 0.05]. Conclusion Immunoglobulin can improve Ig G serum levels in preterm infants, enhance humoral immune function in preterm infants and assist in the treatment of premature infants with sepsis.