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目的研究(S)-1-(2-氯乙酰基)-2-腈基吡咯烷的合成工艺。方法 L-脯氨酸与氯乙酰氯通过N-乙酰化得到(S)-1-(2-氯乙酰基)-2-吡咯烷甲酸,然后加入脲素和氨基磺酸实行分段保温反应得到产物(S)-1-(2-氯乙酰基)-2-腈基吡咯烷。结果此路线所得产品收率为75.5%。结论此工艺路线条件温和、操作简便、原料价廉易得。
AIM To study the synthesis of (S) -1- (2-chloroacetyl) -2-nitrilepyrrolidine. Methods L-Proline and chloroacetyl chloride were obtained by N-acetylation to obtain (S) -1- (2-chloroacetyl) -2-pyrrolidinecarboxylic acid, then adding urea and sulfamic acid The product (S) -1- (2-chloroacetyl) -2-nitrilopyrrolidine. Results The product yield of this route was 75.5%. Conclusion This process route is mild, easy to operate, and inexpensive and readily available raw materials.