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已知仅65%血透患者乙肝疫酋接种后能产生一定量的抗 HBsAg 抗体,对此免疫反应受损有不同的解释。周围血单核细胞增殖反应下降和活化 T 细胞分泌自细胞介素2(IL-2)的缺陷,以及 T 细胞依赖的抗原反应降低的血透患者前活化 T 细胞比例异常增高。前活化 T 细胞数目增加使可溶性 IL-2受体(IL-2R)浓度升高,因 IL-2R 浓度的测定可能与血透患者对乙肝疫苗的反应有关。本文旨在测定各种乙肝疫苗接种的反应以分析不同血透指标对此的影响。
It is known that only 65% of hemodialysis patients with hepatitis B immune system can produce a certain amount of anti-HBsAg antibody after vaccination, for which immune response has different explanations. Decreased peripheral blood mononuclear cell proliferative responses and defects in the secretion of interleukin 2 (IL-2) by activated T cells and an abnormal increase in the proportion of pre-activated T cells in hemodialysis patients with reduced T cell-dependent antigen responses. Increasing the number of pre-activated T cells increases the concentration of soluble IL-2 receptor (IL-2R), which may be due to the response of hemodialysis patients to hepatitis B vaccine. This article aims to determine the response to various hepatitis B vaccinations to analyze the effects of different hemodialysis indices.