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目的 探讨细胞增殖与细胞凋亡在腮腺肿瘤及瘤旁腺泡中的作用。方法 取 44例腮腺肿瘤及瘤旁腺泡作流式细胞术 (FCM )研究。以ModFitLT软件进行细胞增殖分析 ,以Sub -G1法检测凋亡率。结果 腮腺恶性肿瘤的增殖指数 (PI)与凋亡率分别为 2 6 .18%和 2 9.0 2 % ,属最高值 ,其次是良性肿瘤瘤旁腺泡分别为 14 .30 %和 13.41% ,恶性肿瘤瘤旁腺泡分别为 13.45 %和 12 .6 5 % ,良性肿瘤为 9.6 2 %和 9.5 6 %。正常腮腺为 8.0 6 %和6 .6 3%。总体上具有显著性差异 (p <0 .0 5 )。结论 细胞增殖与细胞凋亡在腮腺肿瘤中处于高值 ,而且在腮腺肿瘤瘤旁腺泡中亦处于高值 ,提示瘤旁腺泡可能处于“准新生物”状态 ,它们可能成为肿瘤复发和恶变的发源地。手术时应当一并摘除
Objective To investigate the role of cell proliferation and apoptosis in parotid gland tumor and para-tumorous alveoli. Methods Totally 44 parotid tumors and para-tumorous glands were studied by flow cytometry (FCM). Cell proliferation assay was performed with ModFitLT software and the apoptosis rate was determined by Sub-G1 assay. Results The proliferative index (PI) and apoptosis rate of parotid malignant tumors were 26.18% and 29.02%, respectively, which were the highest value, followed by benign tumor adjacent acini were 14.3% and 13.41% Tumor-adjacent acini were 13.45% and 12.56% respectively, while benign tumors were 9.6% and 9.5% respectively. The normal parotid glands were 8.0 6% and 6.36%. Overall there was a significant difference (p <0.05). Conclusions Cell proliferation and apoptosis are high in parotid tumors and are also high in parotid adenocarcinomas, suggesting that the para-tumorous alveoli may be in a “quasi-neoplasm” state and may be tumor recurrence and malignant The birthplace of Surgery should be removed together