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目的 观察饮酒对二硫化碳 (CS2 )接触者及非接触者尿 2 硫代噻唑烷 4 羧酸 (TTCA)排泄的影响。方法 (1)男性非接触CS2 志愿者 10人 ,一次饮用 38°白酒 15 0ml或 2 5 0ml,高效液相色谱法观察其尿TTCA排泄动态 ;(2 )CS2 作业男工 15 2人 ,非接触者 6 0人 ,分别收集班末尿和晨尿进行TTCA测定并进行问卷调查 ;同时进行个体空气采样和CS2 浓度气相色谱法测定。结果 非接触者一次饮白酒 15 0ml后 3h尿TTCA水平达峰值 ,12h后降至饮前水平 (餐前 0 .5h ,饮酒后 1、3、12h中位数分别为 0 .0 45、0 .0 6 8、0 .0 99、0 .0 46mg/gCr ,n =10 ) ;TTCA水平随饮白酒剂量的增加而增高 ,饮 0、15 0、2 5 0ml白酒者TTCA水平 (中位数 )分别为 0 .0 36、0 .0 6 4、0 .6 0 9mg/gCr(n =5 ,饮后 3h)。CS2 浓度为≤ 10 .0、10 .1～ 5 0 .0、>5 0 .0mg/m3 时 ,CS2 接触者TTCA有随CS2 浓度增高而上升的趋势 ;对照组中饮白酒和啤酒者TTCA水平似高于不饮者 ,而接触组TTCA水平则随饮酒指数的增加而呈降低趋势。结论 大量饮酒可影响尿TTCA水平 ,在进行CS2 生物监测时 ,应避免在大量饮酒后 12h内采集尿样 ,以避免饮酒对监测结果的干扰作用。
Objective To observe the effects of alcohol consumption on urinary 2thothiazolidine 4-carboxylic acid (TTCA) excretion in patients exposed to carbon disulfide (CS2) and non-contact. Methods (1) Ten male non-contact CS2 volunteers were enrolled in this study. They were given 150 ml or 250 ml of 38 ° white wine at one time and their urinary TTCA excretion was observed by high performance liquid chromatography. (2) 15 male CS2 workers, non-contact Sixty individuals were recruited. TTCA and morning urine respectively were collected for TTCA measurement and questionnaire survey. At the same time, individual air samples and CS2 concentration gas chromatography were determined. RESULTS: Urine TTCA reached a peak at 3 hours after non-contact one-time drinking of 150 ml of liquor, and dropped to the level of pre-drink after 12 hours (at 0 .5 hours before meal, the median at 1, 3 and 12 hours after drinking was 0 .0 45,0 respectively. 0 6 8,0 .0 99,0. 0 46mg / gCr, n = 10); TTCA level increased with the increase of drinking liquor dosage, drinking 0,15 0,2 5 0ml white wine TTCA level (median) Respectively 0 .0 36,0 .0 6 4,0. 6 0 9mg / gCr (n = 5, drink 3h). When the concentration of CS2 was ≤10 .0, 10 .1 ~ 5.00, and> 0.05 mg / m3, the TTCA of CS2 contact increased with the increase of CS2 concentration. In the control group, the levels of TTCA Seemed to be higher than those who did not drink, while the contact group TTCA level with the increase of drinking index showed a downward trend. Conclusions A large amount of alcohol consumption may affect the urinary TTCA level. During the CS2 biological monitoring, urine samples should be collected within 12 hours after heavy drinking, so as to avoid the interference of drinking on monitoring results.