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目的 :研究肝硬化患者血浆纤维蛋白原 (Fbg)水平及去肽A后纤维蛋白单体 (desA Afibrinmonomer)的聚合功能。方法 :以蕲蛇酶水解Fbg ,用计算机自动检测系统测定患者血浆中纤维蛋白单体聚合反应速率 (FMPS)、最大吸光度 (Amax)、凝固性纤维蛋白原含量 (FC)、反应延滞时间 (DT)、功能指标 (FI =FMPS/Amax)。结果 :失代偿性肝硬化患者 30例 ,其FMPS为 0 32 6± 0 0 6,Amax为 0 178± 0 0 2 8,FC为 1 70 0± 0 40 0g/L ,DT为 6± 2 0s ,FI为 1 831。除DT外其它数据均较对照组为低。结论 :失代偿性肝硬化患者因纤维蛋白原浓度下降致使纤维蛋白单体聚合功能降低 ,从而出现低凝状态 ,这可能是构成出血倾向的原因之一。
Objective: To investigate the level of plasma fibrinogen (Fbg) and the function of desA Afibrinmonomer after de-peptide A in patients with cirrhosis. Methods: Fbg was hydrolyzed by Agkistrodon acutus, and the plasma fibrin monomer polymerization rate (FMPS), maximal absorbance (Amax), coagulation fibrinogen content (FC) and reaction lag time ), Functional indicators (FI = FMPS / Amax). Results: 30 patients with decompensated cirrhosis had FMPS of 0 32 6 ± 0 0 6, Amax 0 178 ± 0 0 2 8, FC 1 70 0 ± 0 40 0 g / L and DT of 6 ± 2 0s, FI is 1 831. Data other than DT were lower than that of the control group. CONCLUSIONS: In patients with decompensated cirrhosis, there is a hypoconjugation state due to a decrease in fibrin monomer concentration due to a decrease in fibrinogen concentration, which may be one of the causes of bleeding tendencies.