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目的 比较甘露醇和复方甘油在脑缺血急性期的疗效。方法 利用大鼠 Ｍ Ｃ Ａ Ｏ 模型，采用 Ｔ Ｔ Ｃ 染色及光镜观察用药前后梗塞面积大小、缺血组织病理变化特点。结果 甘露醇较复方甘油能更有效地缩小梗塞灶体积，减轻神经元的缺血损伤。结论 甘露醇与复方甘油不仅有脱水作用，而且有脑保护作用，在脑缺血急性期应首选使用甘露醇。
Objective To compare the efficacy of mannitol and compound glycerol in acute stage of cerebral ischemia. Methods M C A O model was used in rats. T T C staining and light microscopy were used to observe the infarct size and pathological changes of ischemic tissue before and after treatment. Results Mannitol than the compound glycerol can more effectively reduce infarct volume, reduce neuronal ischemic injury. Conclusion Mannitol and compound glycerol not only have dehydration effect, but also have brain protective effect. In the acute phase of cerebral ischemia, mannitol should be the first choice.