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通过对大鼠急性出血坏死性胰腺炎（ＡＨＮＰ）动物模型的观察发现：血、肝、心、肺、脑、肾等组织内丙二醛均明显高于正常对照组（Ｐ＜０．０１～０．０５）；胰组织内丙二醛与上述各组织内丙二醛含量呈正相关（ｒ＝０．５２７～０．７８９，Ｐ＜０．００１），与血红细胞超氧化物歧化酶活性呈明显负相关（ｒ＝－０．７６２Ｐ＜０．００１），同时各器官在病理形态上均有不同程度的改变．研究表明，氧自由基在ＡＨＮＰ及其胰外器官损伤过程中起着重要作用，为临床胰腺炎的研究提供了一定的理论基础和实验依据。
Through the observation of acute hemorrhagic necrotizing pancreatitis (AHNP) in rats, malondialdehyde in blood, liver, heart, lung, brain, kidney and other tissues were significantly higher than that in the normal control group (P <0.01 ~ 0.05). There was a positive correlation between malondialdehyde (MDA) and malondialdehyde (MDA) in pancreatic tissues (r = 0.527-0.789, P <0.001), and erythrocyte superoxide dismutase (R = -0.762 P <0.001). At the same time, the pathological changes of various organs varied to some extent. Studies have shown that oxygen free radicals plays an important role in the process of AHNP and its extra-pancreatic organ damage, and provides a theoretical basis and experimental basis for the study of clinical pancreatitis.