慢性肾脏病患者中的骨质疏松症及相关骨折

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骨质疏松是一个全球性的卫生和健康问题.根据1994年WHO定义:骨质疏松是以骨量减少、骨微结构退化为特征伴骨脆性增加和易发生骨折的一种全身性骨骼疾病.因骨质疏松可分为原发性和继发性2大类,故骨质疏松性骨折也可分为2类:一类起因于原发性骨质疏松,主要见于老年人;另一类继发于其他疾病,病理机制复杂.其中,由慢性肾脏病(chronic kidney disease,CKD)引起的骨质疏松,是矿物质及骨代谢异常的表现之一,目前称为CKD合并骨密度低下者.尽管普通人群及CKD患者均可发生骨质疏松症和骨质疏松性骨折,但两者在流行病学、高危因素、影像学以及预防和治疗等方面均有不同,本文就上述几个方面作一综述.
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