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目的通过建立Lewis肺癌病证结合小鼠模型,观察肺抑瘤膏对非小细胞肺癌气滞血瘀质模型的干预作用。方法使用C57BL/6小鼠,建立平和质与气滞血瘀质小鼠模型,并接种Lewis肺癌细胞,造模成功后,随机分两亚组,亚组2予肺抑瘤膏干预,观察瘤体体积、瘤重及血清VEGF-C水平。结果气滞血瘀组亚组1较平和对照组亚组1小鼠在种植瘤瘤体积、瘤重、血清VEGF-C平均光密度方面差异均有统计学意义(P<0.05)。各亚组2肿瘤抑制率、VEGF-C平均光密度与对应的亚组1比较,差异均有统计学意义(P<0.05)。结论气滞血瘀质组较平和质组皮下种植瘤更易生长。肺抑瘤膏能够不同程度地抑制种植瘤的生长,且可能通过抑制VEGF表达而起到治疗作用。
OBJECTIVE: To establish a Lewis lung cancer syndrome-binding mouse model to observe the intervention effects of Lung Yiliu Paste on non-small cell lung cancer with qi stagnation and blood stasis model. Methods C57BL / 6 mice were used to establish mice model of PingQi and qi stagnation and blood stasis, and Lewis lung carcinoma cells were inoculated. After successful modeling, the mice were randomly divided into two subgroups. Body volume, tumor weight and serum VEGF-C levels. Results The qi stagnation and blood stasis group subgroup 1 was more than the control group subgroup 1 mice in tumor volume, tumor weight, serum VEGF-C average optical density differences were statistically significant (P <0.05). The tumor inhibition rate and average optical density of VEGF-C in each subgroup 2 were significantly different from those in subgroup 1 (P <0.05). Conclusion The qi-stagnation and blood-stasis quality group is more likely to grow than the subcutaneous implants of the balance group. Lung tumor suppressant cream can inhibit the growth of implanted tumors to varying degrees, and may play a therapeutic role by inhibiting VEGF expression.