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目的探讨类风湿关节炎(RA)患者能量多普勒(PD)血管指数(VI)与血管内皮生长因子(VEGF)表达的相关性。方法超声检测RA患者46例(活动期21例,缓解期25例),正常对照组30例,利用计算机软件对PD血流信号进行定量分析,采用ELISA法对血VEGF进行定量检测,对二者进行相关性分析。结果活动期与缓解期、对照组血流信号VI值及血清VEGF值比较差异均具有统计学意义(P<0.01)。且两者具有良好相关性(r=0.82,P<0.01)。结论 PD检测RA患者血流与体内促血管生长因子的表达具有一致性,能较好反映疾病不同阶段血管生成状态。
Objective To investigate the correlation between energy Doppler (PD) vascular index (VI) and vascular endothelial growth factor (VEGF) expression in patients with rheumatoid arthritis (RA). Methods 46 patients with RA (21 active, 25 remission) and 30 normal control subjects were enrolled in this study. PD software was used to quantitatively analyze the PD blood flow and the serum levels of VEGF were detected by ELISA. Conduct correlation analysis. Results There were significant differences in VI value of serum flow and serum VEGF between active stage and remission stage (P <0.01). There was a good correlation between them (r = 0.82, P <0.01). Conclusion The detection of PD in blood flow of patients with PD and the expression of angiogenic growth factor in vivo are consistent and can better reflect the angiogenesis status in different stages of the disease.