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对H-Y 抗原的研究最初是由于发现雌性小鼠排斥来自同系雄鼠的皮肤而引起的。Eichwald 等(1955)用纯系动物进行异体皮肤移植试验,发现只有在雄鼠作为供体雌鼠作为受体时才发生排斥反应,这提示雄鼠具有雌鼠所没有的特异性抗原。鉴于雌雄间的遗传物质仅有Y 染色体的差异,该抗原被命名为组织相容性抗原Y,即H-Y 抗原。1971年,Goldberg 等人发现排斥过雄鼠皮肤的雌鼠血清对精子具有细胞毒作用,而且这一活性可以被雄鼠细胞所吸收,但不能被雌鼠的细胞所吸收。这一发现促进了H-Y 抗原的研究。在此基础上许多
The study of H-Y antigen was originally caused by the finding that female mice rejected skin from syngeneic male mice. Eichwald et al. (1955) performed allogeneic skin grafting experiments with purely human animals and found that rejection occurred only when the male was used as a donor female rat. This suggests that male mice have specific antigens that are absent from female mice. Given that there is only a Y chromosome difference between the male and female genetic material, the antigen is designated histocompatibility antigen Y, the H-Y antigen. In 1971, Goldberg et al. found that the serum of a female mouse that has repelled the skin of a male mouse has a cytotoxic effect on sperm, and this activity can be absorbed by a male mouse cell, but cannot be absorbed by a female mouse cell. This discovery promoted the study of H-Y antigen. On this basis many