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头痛、恶心、呕吐是急性高山反应的常见症状。采用口服给药方式，常因呕吐而未能达到应有的疗效。本文采用经皮给药方式，以维持药效的持久作用。首先在实验室观察到东莨菪碱有提高实验动物痛阈的作用，然后在高原观察了耳后粘贴东莨菪碱药膜对防治高原头痛、恶心、呕吐的效果。结果表明给药组的头痛和恶心呕吐发生率均明显低于空白对照组（Ｐ＜０．０５）。同时在现场观察了该药膜对脑血流、心电图的影响，证明该药膜作用安全可靠，而且使用方便。
Headache, nausea, vomiting are common symptoms of acute alpine reactions. Oral administration, often due to vomiting and failed to achieve the desired effect. In this paper, transdermal drug delivery methods to maintain the long-term efficacy of the drug. First observed in the laboratory of scopolamine to improve pain threshold in experimental animals, and then observed in the high altitude scopolamine film attached to the ear on the prevention and treatment of headache, nausea, vomiting effect. The results showed that the incidence of headache and nausea and vomiting were significantly lower than the blank control group (P <0.05). At the same time observed in the field of the film on the cerebral blood flow, ECG, to prove the role of the membrane safe and reliable, and easy to use.