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目的:探讨抗菌药物的应用和血液病患者继发真菌性肠炎的相关性。方法:对2010-2014年血液病科继发真菌性肠炎的住院患者与同期住院的非真菌性肠炎患者抗菌药物应用进行回顾性调查与统计学分析。结果:共确诊60例真菌性肠炎患者,平均年龄(52.43±27.00)岁,真菌性肠炎组使用抗菌药物平均(15.83±8.02)d出现真菌感染,与非真菌性肠炎组有显著性差异;抗菌药物的使用比例和联合应用也远大于非真菌性肠炎组,有显著性差异;导致真菌性肠炎的抗菌药物主要集中在加酶抑制剂、喹诺酮类、林可霉素类和碳青霉烯类。结论:继发真菌性肠炎与抗菌药物的联合使用、时间长短和抗菌药物的品种有关。
Objective: To investigate the relationship between the use of antimicrobial agents and secondary fungal enteritis in patients with blood diseases. Methods: Retrospective investigation and statistical analysis were performed on the use of antimicrobial agents in hospitalized patients with secondary fungal enteritis in the Department of Hematology from 2010 to 2014 and non-mycotic enteritis patients hospitalized in the same period. Results: A total of 60 cases of fungal enteritis were diagnosed, with an average age of (52.43 ± 27.00) years. Fungal infections occurred in the fungal enteritis group with an average of (15.83 ± 8.02) days of antibacterials, which was significantly different from that in the non-fungal enteritis group. The proportion of the use of drugs and joint application is also much larger than non-fungal enteritis group, there were significant differences; leading to fungal enteritis antibacterial drugs are mainly concentrated enzyme inhibitors, quinolones, lincomycin and carbapenems . Conclusion: The combined use of fungal enteritis and antibacterial drugs, the length of time and antibacterial drug varieties.