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目的观察依达拉奉治疗急性大面积脑梗死的疗效及其作用机制。方法 62例急性大面积脑梗死患者随机分为依达拉奉组和对照组。在脑梗死常规治疗基础上,依达拉奉组给予依达拉奉30mg静脉滴注,每天2次,连用2周。观察治疗前后两组神经功能缺损程度评分(NDS)、日常生活能力量表Barthel指数(BI)、血清超氧化物歧化酶(SOD)、脂质过氧化物(LPO)检测,比较两组的疗效。结果两组治疗后NDS比治疗前均有明显降低(均P<0.01),BI指数升高,血清SOD活性升高,LPO含量下降;与治疗前相比,差异有统计学意义(均P<0.01)。与对照组相比,依达拉奉组的变化更显著(均P<0.01);依达拉奉组的总有效率(87.5%)显著高于对照组(66.6%)(P<0.01)。结论依达拉奉具有明显清除自由基的作用,治疗急性大面积脑梗死有肯定的疗效。
Objective To observe the therapeutic effect and mechanism of edaravone on acute large area cerebral infarction. Methods Sixty-two patients with acute massive cerebral infarction were randomly divided into edaravone group and control group. In the conventional treatment of cerebral infarction, edaravone group given edaravone 30mg intravenous infusion, 2 times a day, once every 2 weeks. The degree of neurological deficit (NDS), Barthel index (BI), serum superoxide dismutase (SOD) and lipid peroxide (LPO) were measured before and after treatment. The curative effect of the two groups were compared . Results After treatment, NDS was significantly lower than before treatment in both groups (all P <0.01), BI index increased, serum SOD activity increased and LPO content decreased. Compared with before treatment, the difference was statistically significant (P < 0.01). Compared with the control group, the changes in the edaravone group were more significant (all P <0.01). The total effective rate in the edaravone group (87.5%) was significantly higher than that in the control group (66.6%) (P <0.01). Conclusion Edaravone has a clear role in the removal of free radicals, the treatment of acute large-area cerebral infarction have a positive effect.