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染料木黄酮作为一种蛋白酪氨酸激酶(PTK)特异性抑制剂,已成为国际抗癌药物的研究热点。其主要防癌机制为抑制细胞代谢关键酶活性、调节雌激素受体、增加抗氧化酶的活性及抑制血管生成作用等。现综述染料木黄酮对卵巢肿瘤的抗肿瘤作用及其作用机制研究进展。
Genistein, a specific inhibitor of protein tyrosine kinase (PTK), has become a hot research topic in the field of anticancer drugs. Its main anti-cancer mechanism is to inhibit the key enzyme activity of cellular metabolism, regulating estrogen receptor, increasing the activity of antioxidant enzymes and inhibiting angiogenesis. The progress of the anti-tumor effect of genistein on ovarian tumors and its mechanism of action are reviewed.