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三氮唑核苷,又名病毒唑,是目前临抗床常用的有效抗病毒新药。其含量测定多采用常量定氮法,操作繁琐复杂,测定时间较长。本文根据三氮唑核苷分子中含有共轭双键,在紫外区有特征吸收,经扫描发现其水溶液最大吸收波长为206nm,用于三氮唑核苷及其注射液的含量测定,尚未见报道。本法结果准确,操作简便,灵敏度高,稳定性好,取得较满意结果。一、仪器与试药UV-265FW分光光度计(日本岛津)三氮唑核苷对照品(比旋度-36.4含量99.98％)三氮唑核苷(900702 901015江苏盐城制药厂 901001上海第六制药厂)三氮唑核苷注射液(900801 900803江苏扬州制药厂,901029 90103(江苏兴化制药厂901119 901121 江苏泰州制药厂)二、紫外吸收光谱的测定
Ribavirin, also known as ribavirin, is currently the most effective anti-virus drug commonly used in clinical trials. Determination of the amount of its use of constant nitrogen method, cumbersome and complicated operation, measurement time is longer. In this paper, ribavirin molecules contain conjugate double bonds and have characteristic absorption in the ultraviolet region. The maximum absorption wavelength of the aqueous solution was found to be 206 nm after scanning. It has not been found for the determination of ribavirin and its injection Reported. The method is accurate, easy to operate, high sensitivity, good stability and more satisfactory results. First, the instrument and reagent UV-265FW spectrophotometer (Japan Shimadzu) Ribavirin reference substance (Specific rotation -36.4 content 99.98%) Ribavirin (900,702 90,101 Jiangsu Yancheng Pharmaceutical Factory 901001 Shanghai sixth Pharmaceutical Factory) Ribavirin Injection (900801 900803 Jiangsu Yangzhou Pharmaceutical Factory, 901029 90103 (Jiangsu Xinghua Pharmaceutical Factory 901119 901121 Jiangsu Taizhou Pharmaceutical Factory) Second, the determination of ultraviolet absorption spectrum