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宫内感染对妊娠的影响及对母儿造成的危害日益受到关注,其可导致早产及围生儿死亡、新生儿呼吸窘迫综合征等不良妊娠结局;但目前以临床诊断为主,使许多亚临床感染的孕产妇得不到及时诊治,而宫内感染一旦出现临床症状时病情往往已经危重,近年,预测宫内感染的相关研究成为热点。研究表明,白细胞介素10、粒细胞集落刺激因子、白细胞介素6、基质金属蛋白酶9、高迁移率族蛋白1、人类β防御素等细胞因子对宫内感染有一定的预测价值,联合蛋白组学方法可能实现宫内感染的早期诊断、早期治疗。综述宫内感染预测的相关细胞因子的研究近况。
The impact of intrauterine infection on pregnancy and harm to mothers and children is receiving increasing attention, which can lead to adverse pregnancy outcomes such as preterm birth and perinatal death, neonatal respiratory distress syndrome, etc. However, clinical diagnosis is currently the mainstay of many intrauterine infections Clinical infection of pregnant women can not get timely diagnosis and treatment, and intrauterine infection in the event of clinical symptoms have often been critically ill, in recent years, prediction of intrauterine infection related research has become a hot spot. Studies have shown that interleukin 10, granulocyte colony stimulating factor, interleukin 6, matrix metalloproteinase 9, high mobility group box 1, human β-defensin and other cytokines have certain predictive value of intrauterine infection, the joint protein Group method may achieve early diagnosis of intrauterine infection, early treatment. Review of recent studies on the related cytokines predicted by intrauterine infection.