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作者根据实验室病毒分离(A_2型)及临床观察资料,对流感的发病机制提出了新的看法。实验资料指出,A_2型流感病毒不仅在人的呼吸道上皮可以繁殖,而且也能在其他的上皮和内皮组织内繁殖,包括人的肾、皮肤及猿的肾和脑膜等。因此,以往认为流感病毒具有“嗜肺性”,只能在上呼吸道上皮(或有时在肺组织)繁殖的见解应该加以修正。基于1959年 A_2型病毒所致流感流行的临床资料,上述见解的正确性得到了进一步的证实。比如在320名病例中,从191例的鼻咽含漱液中发现了流感病毒,36例中,在
According to the laboratory virus isolation (A_2 type) and clinical observation data, the author put forward a new view on the pathogenesis of influenza. According to the experimental data, A 2 influenza virus can not only breed in the human respiratory epithelium but also in other epithelial and endothelial tissues, including human kidney, skin and ape kidney and meninges. Therefore, in the past, the opinion that influenza virus has “addicted to pneumonia” and should only be propagated in the upper respiratory epithelium (or sometimes in lung tissue) should be corrected. The correctness of the above findings has been further substantiated based on the clinical data of the influenza A 2 virus epidemic in 1959. For example, in 320 cases, influenza virus was found in 191 cases of nasopharyngeal gargle, and in 36 cases,