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目的 观察健康人尿铜蓝蛋白排泄率 (CER)随增龄发生的变化 ,并探讨其临床意义。 方法 对 314名 2 0～ 79岁健康者以 10岁为一年龄段分成 6组。采用酶联免疫吸附测定法检测其尿CER。 结果 各年龄组尿CER为 :2 0～ 2 9岁组 (38± 19)ng/min、30～ 39岁组 (42± 2 4 )ng/min、4 0～ 4 9岁组 (45± 2 5 )ng/min、5 0～ 5 9岁组 (48± 32 )ng/min、6 0～ 6 9岁组 (5 3± 33)ng/min、70～ 79岁组 (6 1± 4 3)ng/min ,但各年龄组间差异无显著性 (P >0 0 5 )。非老年组 (47± 30 )ng/min ,老年组(5 9± 39)ng/min ,两组比较差异有显著性 (P <0 0 5 )。 结论 (1)增龄过程中尿CER有上升的趋势 ;(2 )尿CER老年组明显高于非老年组 ;(3)对老年患者的临床诊断治疗要考虑因年龄因素而存在的脏器排泄率变化。
Objective To observe the change of urinary ceruloplasmin excretion rate (CER) of healthy people with increasing age, and to explore its clinical significance. Methods A total of 314 healthy people aged 20-79 years old were divided into 6 groups at the age of 10. Enzyme-linked immunosorbent assay was used to detect urine CER. Results The urine CER in all age groups was (38 ± 19) ng / min from 20 to 29 years old, 42 ± 2 4 ng / min from 30 to 39 years old (45 ± 2) (5 ± 5) ng / min, 48 ± 32 ng / min in 50-59 years old group (53 ± 33) ng / min in 6 0 ~ 69 years old group ) ng / min, but there was no significant difference among all age groups (P> 0.05). Non-elderly group (47 ± 30) ng / min, elderly group (59 ± 39) ng / min, the difference between the two groups was significant (P <0 05). Conclusions (1) There is a trend of increasing urinary CER during aging; (2) Urine CER elderly group is significantly higher than that of non-elderly group; (3) Excretion of organs due to age is considered in the clinical diagnosis and treatment of elderly patients Rate changes.