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俄咪普唑对胃酸分泌有强大的抑制作用,且副作用少。对胃及十二指肠溃疡的疗效与H_2受体阻滞剂相似。治疗Zollinger-Ellison综合征,优于H_2受体阻滞剂。是一种有发展前途的抗消化性溃疡新药。 药理作用和机理 吸收过程 俄咪普唑是一种弱碱性药物(pKa=4),在小肠碱性条件下吸收。胃酸虽可使该药转化成活性形式,但也会加速其灭活。常以肠溶颗粒给药。给药开始时,吸收不规则。随着给药次数的增加,胃内pH升高,吸收可明显改善。一次性给药,20min出现最大吸收。8～11h药物从血浆消失。
Omeprazole has a strong inhibitory effect on gastric acid secretion, and fewer side effects. Efficacy on gastric and duodenal ulcers similar to H 2 receptor blockers. Treatment of Zollinger-Ellison syndrome, better than H 2 blockers. Is a promising new anti-peptic ulcer drugs. Pharmacological effects and mechanism of absorption Omeprazole is a weakly basic drug (pKa = 4), absorbed in the small intestine under alkaline conditions. Although gastric acid can convert the drug into an active form, it also accelerates its inactivation. Administration of enteric granules often. Absorption is irregular at the start of dosing. With the increase in the number of dosing, gastric pH, absorption can be significantly improved. One-time administration, 20min appeared maximum absorption. 8 ~ 11h drug disappeared from the plasma.