用离体豚鼠心乳头状肌观察苄基四氢巴马汀(BTHP)对其生理特性及对心肌细胞动作电位的影响。结果表明BTHP 80μM明显延长功能性不应期,抑制肾上腺素诱发的自律性,对兴奋性则影响不大。对动作电位,5-100μM BTHP可延长ERP和APD,这种作用呈浓度和时间依赖性,但对Fc、APA、和Vmax则无明显影响。BTHP 50μM还能显著减慢用利血平处理及未处理的离体豚鼠右房频率,对左房收缩力则稍有增加。结果提示降低心肌自律性、延长ERP和APD与BTHP抗心律失常的机理有关。 Effects of benzyl tetrahydropalmatine (BTHP) on the physiological characteristics and action potential of cardiomyocytes in guinea pig papillary. The results showed that BTHP 80μM significantly prolonged functional refractory period, inhibition of adrenaline-induced self-discipline, excitability was not affected. For action potential, 5-100μM BTHP prolonged ERP and APD in a concentration- and time-dependent manner but with no significant effect on Fc, APA, and Vmax. BTHP 50μM also significantly slowed the right atrial frequency of isolated guinea pigs treated and not treated with reserpine, while slightly increasing left atrial contractility. The results suggest that reducing myocardial autonomy, prolonged ERP and APD and BTHP anti-arrhythmia mechanism.