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目的探讨妊娠期外阴阴道念珠菌的治疗和预防方法。方法对照组给予制霉素栓20万U/d,阴道给药,连用7d;治疗组给予正美汀500mg/d,阴道给药1次即可,两组均初次治疗后10d重复治疗两次,共3个疗程。结果两组治疗后1周的总有效率对照组为85%,治疗组为95.12%,差异无统计学意义;但治疗后2个月对照组复发率为17.5%,而治疗组为0;治疗后3个月对照组复发率为20.00%,治疗组复发率为2.44%。两组在2个月及3个月复发率的比较差异有统计学意义(P<0.05)。结论正美汀治疗加间歇预防给药对妊娠期外阴阴道念珠菌感染的治疗与预防复发效果满意。
Objective To investigate the treatment and prevention of vulvovaginal candidiasis in pregnancy. Methods The control group was treated with nystatin 200 000 U / d vaginally for 7 days. The patients in the treatment group were treated with Zhengmeiting 500mg / d and the vagina was given once. The patients in both groups were treated twice a day for 10 days, A total of 3 courses. Results The total effective rate of one week after treatment was 85% in the control group and 95.12% in the treatment group, but the difference was not statistically significant. However, the recurrence rate of the control group was 17.5% at 2 months after treatment, while the treatment group was 0; The recurrence rate was 20.00% in the control group after 3 months and 2.44% in the treatment group. The recurrence rates of the two groups at 2 months and 3 months were significantly different (P <0.05). Conclusions Zhengmeiting treatment plus intermittent prophylaxis is satisfactory for the treatment and prevention of recurrent vulvovaginal candidiasis in pregnancy.