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应用嗜银染色和免疫组化技术研究胆囊癌组织中内分泌细胞及其意义。４０例胆囊癌嗜银染色阳性者１０例，均为女性，７例发生癌转移，７例伴胆囊结石。免疫组化结果表明：嗜银染色阳性者，免疫组化多为阳性，其中ＥＭＡ，ＣＥＡ，ＨＣＧ阳性各７例；ＰＮＡ，ＣｏｎＡ，ＳＭ各５例；ＧＮ４例。结果提示部分胆囊癌病例内分泌细胞染色阳性，且阳性病例可能预后不良。
Using silver staining and immunohistochemistry to study endocrine cells in gallbladder carcinoma and their significance. Among the 40 cases with gallbladder carcinoma positive for silver staining, 10 cases were female, 7 cases had cancer metastasis, and 7 cases had gallstones. The results of immunohistochemistry showed that those with positive silver staining were mostly immunohistochemically positive, with EMA, CEA, and HCG positive in 7 cases respectively, PNA, ConA, SM in 5 cases, and GN in 4 cases. The results suggest that some cases of gallbladder carcinoma endocrine cells were positive for staining, and positive cases may have poor prognosis.