原发性肝细胞癌癌前病变血液动力学的MR实验研究

来源 :中华放射学杂志 | 被引量 : 0次 | 上传用户:wenjun456852
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的探讨原发性肝细胞癌(HCC)癌前病变血液动力学的特征。方法用MR灌注扫描(MR perfusion,MRP)的方法对实验诱发大鼠肝脏的HCC癌前病变阶段到癌变阶段的血液动力学进行动态观察。结果在MR T2WI检出并与病理对应良好的46个结节中有9个再生结节(regenerative nodule,RN)、22个HCC癌前病变即发育不良结节(dysplastic nodule,DN)、10个早期HCC和5个HCC。RN、DN、早期HCC和HCC结节及邻近肝实质的平均阳性强化积分值(positiveenhancement integral,PEI)分别为205·67±31·17、161·94±20·74、226·09±34·83、491·86±44·61、204·84±70·19。将结节PEI值和结节旁肝组织PEI值对比,发现9个RN与邻近肝实质差异无统计学意义(t=-5·30,P=0·06),MRP图像的动脉期和门脉期RN均呈等信号;DN较邻近肝实质低,并有统计学意义(t=-3·64,P=0·02),DN的血流灌注曲线于动脉后期较邻近肝实质下降,MRP图像动脉期呈等信号,门脉期为低信号。10个早期HCC中4个结节表现为低灌注,PEI值低于邻近肝实质,动脉期呈稍低信号,门脉期为等信号;6个早期HCC显示为稍高灌注,PEI值稍高于邻近肝实质,动脉期为稍高信号,门脉期呈稍低信号。5个HCC呈典型的动脉期明显强化、门脉期呈相对低信号,结节灌注曲线动脉段较邻近肝实质有明显抬高,结节较邻近肝实质的PEI明显增大,差异有统计学意义(t=3·74,P=0·02)。结论MRP能反映HCC癌前病变结节演变过程中血流的改变,HCC的血流灌注量较邻近肝实质明显增多;DN的血流灌注量较邻近肝实质减少。 Objective To investigate the hemodynamic characteristics of precancerous lesions in primary hepatocellular carcinoma (HCC). Methods The MR perfusion (MRP) method was used to observe the hemodynamics of HCC precancerous lesions and carcinogenesis in experimental rats. Results Among the 46 nodules detected by MR T2WI and corresponding well with pathology, there were 9 regenerative nodules (RNs), 22 HCC precancerous lesions (dysplastic nodules, DN), 10 Early HCC and 5 HCCs. The average positive PEI for RN, DN, early HCC and HCC nodules and adjacent liver parenchyma were 205.67 ± 31.17, 161.94 ± 20.74, 22.69 ± 34.0 83,491 · 86 ± 44 · 61, 204 · 84 ± 70 · 19. Comparing the nodule PEI value with the nodal liver tissue PEI value, we found there was no significant difference between the 9 RN and the adjacent liver parenchyma (t = -5 · 30, P = 0.06). The arterial phase and the gate The RN of RN was equal signal in the pulse phase. DN was lower than that of the adjacent liver and had statistical significance (t = -3.64, P = 0.02). The perfusion curve of DN decreased in the late arterial phase compared with the adjacent liver parenchyma, MRP images showed arterial phase signal, portal phase is low signal. The four nodules of 10 early HCC showed hypoperfusion, PEI value was lower than adjacent liver parenchyma, arterial phase was slightly lower signal, portal phase is equal signal; 6 early HCC showed slightly hyperperfusion, PEI value slightly higher In the vicinity of the liver parenchyma, the arterial phase is slightly higher signal, the portal vein was slightly lower signal. Five HCC showed typical arterial phase was significantly enhanced, portal phase was relatively low signal, nodular perfusion curve artery segment was significantly higher than the adjacent liver parenchyma, adjacent to the liver parenchyma PEI significantly increased, the difference was statistically significant Significance (t = 3.74, P = 0.02). Conclusions MRP can reflect the changes of blood flow during the development of precancerous lesions of nodules. The perfusion of HCC is obviously higher than that of adjacent parenchyma. The blood perfusion of DN is lower than that of adjacent parenchyma.
其他文献
多协议标签交换(MPLS)技术实现IP网络的流量工程、虚拟专网、服务质量保证.本文建立了标签交换路由器(LSR)功能模型,以此模型基础设计了基于软硬件协同工作的LSR架构.利用灵
目的评价广角激光扫描血管造影技术在脉络膜黑色素瘤诊断中的应用价值。方法将24例临床诊断为脉络膜黑色素瘤的患者随机分为两组,分别应用激光扫描检眼镜的广角接触镜系统和
目的:探讨肌苷注射液对尾部悬吊大鼠比目鱼肌(SOL)梭内、外肌纤维肌球蛋白重链(MHC)表达的影响.方法:采用大鼠尾部悬吊法建立后肢骨骼肌废用模型,用免疫组化染色法检测肌苷注
目的了解从黑天鹅分离H5N1亚型流感病毒株血凝素基因特性.方法用RT-PCR扩增目的基因,用PGBM-TVecTor(美国Promeqa公司)4℃过夜连接重组质检转入dH5α细菌,筛选阳性菌落,酶切
目的探讨血管紧张素(17)[Ang(17)]对高血压大鼠血管内皮功能的影响。方法采用腹主动脉缩窄术制成高血压大鼠模型,45只SD大鼠分为假手术组、模型对照组、Ang(17)治疗组[25μg/
目的总结不宜或不能行多层螺旋CT(MSCT)冠状动脉检查的心率过快、心律不齐、起搏器置入患者应用新一代电子束CT(EBCT)行无创冠状动脉成像的初步经验。方法患者36例,其中心率
目的探讨罗格列酮对载脂蛋白 E(apoE)基因敲除小鼠主动脉粥样硬化斑块稳定性的影响及其可能机制。方法 32只6周龄 apoE 基因敲除小鼠随机分为罗格列酮组(18只)和对照组(14只)
目的研究肺炎衣原体(CP)呼吸道感染暴发流行的临床特征及胸部影像学表现。方法15例暴发流行的CP呼吸道感染住院患者(1例为原发病例,14例为医护人员)痰和咽拭子标本,应用聚合
目的通过比较MR平扫、应用对比剂钆喷替酸葡甲胺(Gd-DTPA)增强MRI及MRI特异性对比剂铁羧葡胺增强MRI对肝脏局灶性病变的检出,验证铁羧葡胺在病灶检出方面的优势.方法 2003年1
目的探讨胰岛素样生长因子I型受体(insulin-like growth factor I receptor,IGF-I R) 在人结肠癌细胞株HT-29上的表达,以及两种胰岛素样生长因子I型受体单克隆抗体(IGF-I R M