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目的:评价脑心通胶囊对急性苯中毒大鼠的保护作用。方法:用苯溶液多点皮下注射建立急性苯中毒大鼠模型。将实验动物分为正常组、造模组、脑心通预防组。观察各组大鼠血常规白细胞计数和超氧化物歧化酶(SOD)活性改变。结果:与正常组比较,造模组血常规白细胞计数下降,SOD活性升高,差异有统计学意义。脑心通预防组SOD活性低于造模组,差异有统计学意义,血常规白细胞计数值高于造模组,但差异无统计学意义。结论:脑心通能减轻急性苯中毒对大鼠的损伤,其作用机制可能与间接调节SOD的活性有关。
Objective: To evaluate the protective effect of Naoxintong capsule on acute benzene poisoning rats. Methods: Acute benzene poisoning rat model was established by multiple subcutaneous injection with benzene solution. The experimental animals were divided into normal group, model group, Naoxintong prevention group. The changes of blood routine white blood cell count and superoxide dismutase (SOD) activity in each group were observed. Results: Compared with the normal group, the blood routine white blood cell count decreased and the SOD activity increased in the model group, the difference was statistically significant. Naoxintong prevention group SOD activity was lower than the model group, the difference was statistically significant, blood leukocyte count higher than the model group, but the difference was not statistically significant. Conclusion: Naoxintong could reduce the damage of acute benzene poisoning in rats, which may be related to the indirect regulation of the activity of SOD.