恶性淋巴瘤属世界十大最常见恶性肿瘤之一,近来其流行率每年以7%迅速增长。过去数年对于这种疾病的发病机制已经获得一些新的认识,明确了转化和进展的关健基因。与之相反,近十余年治疗的进展却相对甚微:患高度恶变的淋巴瘤病人虽然用化疗,基本上能得到痊愈应答,50%～70%的病例获完全缓解(CR)。但是,40%～60%的患者复发,最终死亡。伴 Malignant lymphoma is one of the ten most common malignancies in the world, and its prevalence has recently grown rapidly at a rate of 7% annually. The past few years have gained some new insights into the pathogenesis of this disease and have identified key genes for transformation and progression. In contrast, the progress of treatment in the past decade or so has been relatively modest: Patients suffering from highly malignant lymphomas are basically able to recover with chemotherapy, and 50% to 70% of cases receive complete remission (CR). However, 40% to 60% of patients relapsed and eventually died. Company