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目的:探讨血栓弹性图监测二磷酸腺苷（ADP）途径诱导的血小板功能障碍与创伤性脑损伤患者院内病死率的相关性研究。方法:回顾性分析浙江衢化医院2016年1月至2018年12月180例创伤性脑损伤患者的临床资料。患者均行血栓弹力图检查，其中ADP途径诱导的血小板抑制率（ADP抑制率） ≤ 60%为非ADP功能障碍组（74例），ADP抑制率>60%为ADP功能障碍组（106例）。多元Logistic回归分析患者院内病死率的独立影响因素，采用Logistic回归模型分析ADP抑制率预测院内病死率的阈值。结果:两组性别构成、年龄、凝血酶原时间、国际标准化比率、活化部分凝血活酶时间、血小板计数、收缩压、脉搏、入院到血栓弹力图检查时间、格拉斯昏迷评分、创伤严重度评分、简易创伤定级标准及入院前抗血小板药物使用情况比较差异无统计学意义（n P>0.05）；ADP功能障碍组入院后插管率和院内病死率明显高于非ADP功能障碍组［69.8%（74/106）比37.8%（28/74）和32.1%（34/106）比8.1%（6/74）］，差异有统计学意义（n P60%和创伤严重度评分是创伤性脑损伤患者院内病死率增加的独立预测因素（n OR = 6.21和1.13，95% n CI 1.21～31.27和1.05～1.22，n P60%是预测患者院内病死率的阈值（n OR = 6.18，95% n CI 1.2～33.3）。n 结论:血栓弹力图中的ADP抑制率与创伤性脑损伤患者的院内病死率有关。“,”Objective:To investigate the relationship between adenosine diphosphate (ADP) pathway-induced platelet dysfunction monitoring by thrombelastography with hospital mortality in patients with traumatic brain injury.Methods:The clinical data of 180 patients with traumatic brain injury in Zhejiang Quhua Hospital from January 2016 to December 2018 were retrospectively analyzed. The patients underwent thrombelastography examination. Among them, the ADP pathway-induced platelet inhibition rate (ADP inhibition rate) ≤ 60% was in 74 cases (non-ADP dysfunction group), and ADP inhibition rate > 60% was in 106 cases (ADP dysfunction group). Multiple Logistic regression analysis was used to analyze the independent influencing factors of patients′ hospital mortality. Logistic regression model was used to analyze the threshold of ADP inhibition rate to predict hospital mortality.Results:There were no statistical differences in the gender composition, age, prothrombin time, international standardized ratio, activated partial thromboplastin time, platelet count, systolic blood pressure, pulse, admission to thrombelastography examination time, Glasgow coma score, trauma severity score, simple trauma grading criteria and using of antiplatelet drugs before admission between 2 groups (n P>0.05). The intubation rate and in-hospital mortality in ADP dysfunction group were significantly higher than those in non-ADP dysfunction group: 69.8% (74/106) vs. 37.8% (28/74) and 32.1% (34/106) vs. 8.1% (6/74), and there were statistical differences (n P60% and trauma severity score were independent predictors of increased hospital mortality in patients with traumatic brain injury (n OR = 6.21 and 1.13, 95% n CI 1.21 to 31.27 and 1.05 to 1.22, n P60% was the threshold for predicting the hospital mortality rate (n OR = 6.18, 95% n CI 1.2 to 33.3).n Conclusions:ADP inhibition rate of thrombelastography is related to the hospital mortality in patients with traumatic brain injury.