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目的 探讨膀胱镜活检组织CD44蛋白表达与膀胱肿瘤恶性程度及转移的关系。方法 应用流式细胞仪和免疫荧光技术对35例膀胱移行细胞癌、17例良性病变和12例正常膀胱粘膜组织进行CD44蛋白表达检测。结果 发现膀胱移行细胞癌病灶CD44表达明显高于良性病变和正常粘膜,具有显著差异(P<0.01);CD44表达在浸润性膀胱癌明显高于浅表性膀胱癌,有显著差异(P<0.05),癌前病变即开始出现高表达趋势。结论 CD44与肿瘤的浸润和转移密切相关。膀胱镜活检组织中CD44蛋白含量的测定在膀胱移行细胞癌的早期诊断、转移潜能预测和术前决策方面有很大临床价值。
Objective To investigate the relationship between the expression of CD44 protein in cystoscopic biopsies and the malignancy and metastasis of bladder neoplasms. Methods Flow cytometry and immunofluorescence were used to detect the expression of CD44 protein in 35 cases of bladder transitional cell carcinoma, 17 cases of benign lesions and 12 cases of normal bladder mucosa. The results showed that the expression of CD44 in bladder transitional cell carcinoma was significantly higher than that in benign and normal mucosa (P <0.01). CD44 expression was significantly higher in invasive bladder cancer than in superficial bladder cancer (P <0.05) ), Precancerous lesions began to appear high expression trend. Conclusion CD44 is closely related to tumor invasion and metastasis. The determination of CD44 protein in cystoscope biopsy has great clinical value in the early diagnosis of bladder transitional cell carcinoma, metastasis potential prediction and preoperative decision-making.