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目的：观察氧氟沙星与环丙沙星对小儿伤寒的治疗效果并评价其安全性。方法：对６４ 例确诊为伤寒的患儿随机分为两组，３０ 例采用氧氟沙星治疗，３４ 例应用环丙沙星，均按１０ｍｇｋｇｄ ，分２ 次静注，热退后再用３ｄ 。结果：氧氟沙星开始退热时间、体温降至正常时间、显效率均明显优于环丙沙星（ Ｐ＜ ００１） ，两组在用药过程中个别出现消化道症状、皮疹、均在停药后消失，未见关节肿痛，随访无生长迟缓等现象发生。结论：氧氟沙星、环丙沙星是治疗小儿伤寒安全有效的喹诺酮类药物，氧氟沙星疗效优于环丙沙星。
Objective: To observe the effect of ofloxacin and ciprofloxacin on the treatment of typhoid fever in children and evaluate its safety. Methods: 64 cases diagnosed as typhoid fever were randomly divided into two groups, 30 cases were treated with ofloxacin, 34 cases were treated with ciprofloxacin, 10mg kg d, 2 intravenous injection, heat back Then use 3d. Results: ofloxacin began to extubation time, body temperature dropped to normal time, the apparent efficiency were significantly better than ciprofloxacin (P <0 01), the two groups in the course of the individual gastrointestinal symptoms, rash, both Disappeared after stopping, no joint swelling and pain, follow-up no growth retardation and other phenomena. CONCLUSION: Ofloxacin and ciprofloxacin are safe and effective quinolones for pediatric typhoid fever. Ofloxacin is superior to ciprofloxacin.