钙在一系列的生理活动中起着非常重要的作用 ,尤其离子钙在细胞信号传导方面的作用更为重要 ,如果过量的钙进入细胞内以及不能维持细胞内钙动态平衡 ,将导致细胞死亡及组织坏死〔1〕。钙通道阻滞剂是指在通道水平上选择性的阻滞Ｃａ2 +经细胞膜上的电压依赖性的钙通道进入细胞 Calcium plays a very important role in a series of physiological activities. In particular, the role of ionized calcium in cell signaling is even more important. If excess calcium enters the cells and the inability to maintain intracellular calcium homeostasis results in cell death and Tissue necrosis 〔1〕. Calcium channel blockers are those that selectively block the passage of Ca2 + into the cells via a voltage-dependent calcium channel on the cell membrane at the channel level